NTP CHEMICAL REPOSITORY (RADIAN CORPORATION, AUGUST 29, 1991) METHYLENE CHLORIDE -IDENTIFIERS =========== *CATALOG ID NUMBER: 000491 *CAS NUMBER: 75-09-2 *BASE CHEMICAL NAME: METHYLENECHLORIDE *PRIMARY NAME: METHYLENE CHLORIDE *CHEMICAL FORMULA: CH2Cl2 *STRUCTURAL FORMULA: CH2Cl2 *WLN: G1G *SYNONYMS: METHANE DICHLORIDE DICHLOROMETHANE METHYLENE BICHLORIDE METHYLENE DICHLORIDE AEROTHENE MM DCM NARKOTIL SOLAESTHIN SOLMETHINE NCI-C50102 R 30 RCRA WASTE NUMBER U080 UN 1593 -PHYSICAL CHEMICAL DATA ====================== *PHYSICAL DESCRIPTION: LITERATURE: Clear colorless liquid REPOSITORY: Clear liquid *MOLECULAR WEIGHT: 84.93 *SPECIFIC GRAVITY: 1.326 @ 20/4 C [043,051] *DENSITY: 1.3255 g/mL @ 20 C [173,421] *MP (DEG C): -96.7 C [038,205,421,430] *BP (DEG C): 39.8 C @ 760 mm Hg [051,058,102,371] *SOLUBILITIES: WATER : 10-50 mg/mL @ 21 C (RAD) DMSO : >=100 mg/mL @ 21 C (RAD) 95% ETHANOL : >=100 mg/mL @ 21 C (RAD) METHANOL : Not available ACETONE : >=100 mg/mL @ 21 C (RAD) TOLUENE : Not available OTHER SOLVENTS: Alcohol: Miscible [031,173,205,295] Ether: Miscible [031,173,205,295] Ethanol: >10% [047] Dimethylformamide: Miscible [031,173,205] Most organic solvents: Completely miscible [421] *VOLATILITY: Vapor pressure: 440 mm Hg @ 25 C [301,421,430] Vapor density : 2.93 [043,055,058,395] *FLAMMABILITY(FLASH POINT): Literature sources indicate that this chemical is nonflammable under normal conditions [062,173,371,421]. However, it is flammable from 12%-19% in air with high ignition energy [036,043,066]. This compound is not explosive when mixed with air but may form explosive mixtures in atmospheres with higher oxygen content [043,051,395]. It forms flammable vapor-air mixtures at >=100 C [051,451]. Fires involving this material can be controlled with a dry chemi- cal, carbon dioxide or Halon extinguisher. A water spray may also be used [058]. The autoignition temperature of this compound is 556 C (1033 F) [102, 451]. *UEL: 19% [058,102,371,451] LEL: 12% [058,102,371,451] *REACTIVITY: This chemical reacts vigorously with active metals such as lithium, sodium and potassium, and with strong bases such as potassium tert-butoxide [051,395,451]. It is incompatible with strong oxidizers, strong caustics and chemically active metals such as aluminum or magnesium powders [051, 058,102,346]. The liquid will attack some forms of plastic, rubber and coatings [102]. This compound reacts with sodium-potassium alloy, (potassium hydrogen + N-methyl-N-nitrosurea), nitrogen tetroxide and liquid oxygen. It also reacts with titanium. On contact with water it corrodes iron, some stainless steels, copper and nickel [051]. It is incompatible with alkali metals [058,269]. It is incompatible with amines, zinc and alloys of alumi- num, magnesium and zinc [058]. This compound is liable to explode when mixed with dinitrogen pentoxide or nitric acid [036]. Mixtures of this compound in air with methanol vapor are flammable [043]. *STABILITY: This chemical is sensitive to heat [043,269]. It is also sensitive to exposure to moisture [058]. It is subject to slow hydrolysis which is accelerated by light [051]. Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab conditions (RAD). *OTHER PHYSICAL DATA: Specific gravity: 1.36174 @ 0/4 C; 1.33479 @ 15/4 C; 1.30777 @ 30/4 C [031] Density: 1.321 g/mL @ 25 C [047] Vapor pressure: 20 mm Hg @ -33.4 C; 40 mm Hg @ -22.3 C [038] Vapor pressure: 60 mm Hg @ -15.7 C; 100 mm Hg @ -6.3 C [038] Vapor pressure: 200 mm Hg @ 8.0 C; 400 mm Hg @ 24.1 C [038] Vapor pressure: 500 mm Hg @ 30 C [055]; 349 mm Hg @ 20 C [055,058] Vapor pressure: 380 mm Hg @ 22 C [043,051]; 760 mm Hg @ 40.7 C [038] Not unpleasant, sweetish odor above 300 ppm; odor becomes unpleasant ~1000 ppm [430] log P octanol: 1.25 [395] Odor threshold: 205-307 ppm [051,371] UV max: 400-340 nm, 260 nm, 250 nm, 240 nm, 235 nm [275] Evaporation rate (butyl acetate = 1): 27.5 [102] Evaporation rate (ethyl ether = 1): 0.71 [058] Critical temperature: 245 C [051,371] Critical pressure: 60.9 atm [051,371] Latent heat of vaporization: 78.7 cal/g [051,371] Heat of fusion: 16.89 cal/g [051,371] pH of solutions: neutral [058] 100% volatile by volume [058] Viscosity: 0.430 centipoise @ 20 C [062] Refractive index: 1.4244 @ 20 C [031,052,062] -TOXICITY ======== *NIOSH REGISTRY NUMBER: PA8050000 *TOXICITY: typ. dose mode specie amount units other LDLo orl hmn 357 mg/kg TCLo ihl hmn 500 ppm/1Y-I TCLo ihl hmn 500 ppm/8H LC50 ihl rat 88000 mg/m3/30M LC50 ihl mus 14400 ppm/7H LD50 scu mus 6460 mg/kg LCLo ihl dog 14108 ppm/7H LDLo ipr dog 950 mg/kg LDLo scu dog 2700 mg/kg LDLo ivn dog 200 mg/kg LCLo ihl cat 43400 mg/m3/4.5H LDLo orl rbt 1900 mg/kg LCLo ihl rbt 10000 ppm/7H LDLo scu rbt 2700 mg/kg LCLo ihl gpg 5000 ppm/2H LD50 unr mus 4770 mg/kg LD50 orl rat 1600 mg/kg LD50 ipr rat 916 mg/kg LD50 ipr mus 437 mg/kg LDLo orl dog 3 gm/kg *AQTX/TLM96: Not available *SAX TOXICITY EVALUATION: THR: Poison by intravenous route. Moderately toxic by ingestion, subcutaneous and intraperitoneal routes. Mildly toxic by inhalation. An experimental carcinogen and tumorigen. An experimental teratogen. Experimental reproductive effects. An eye and severe skin irritant. Human mutagenic data. *CARCINOGENICITY: Tumorigenic Data: TCLo: ihl-rat 3500 ppm/6H/2Y-I TCLo: ihl-mus 2000 ppm/5H/2Y-C TC : ihl-rat 500 ppm/6H/2H-I Review: IARC Cancer Review: Animal Sufficient Evidence IARC Cancer Review: Human Inadequate Evidence IARC possible human carcinogen (Group 2B) [015,395,610] Status: NTP Carcinogenesis Studies (Inhalation); Clear Evidence: Female Rat, Male and Female Mouse [015,620] NTP Carcinogenesis Studies (Inhalation); Some Evidence: Male Rat [620] ACGIH suspected human carcinogen [610] NTP anticipated human carcinogen [610] *MUTATION DATA: See RTECS printout for data *TERATOGENICITY: See RTECS printout for data *STANDARDS, REGULATIONS & RECOMMENDATIONS: OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z Transitional Limit: PEL-TWA 500 ppm; Ceiling Limit 1000 ppm; Peak 2000 ppm/5M/2H [015,327,545,610] Final Limit: PEL-TWA 500 ppm [610] ACGIH: TLV-TWA 50 ppm [015,415,421,610] NIOSH Criteria Document: Recommended Exposure Limit to this compound-air: Reduce exposure to lowest feasible limit [610] NFPA Hazard Rating: Health (H): 2 Flammability (F): 1 Reactivity (R): 0 H2: Materials hazardous to health, but areas may be entered freely with full-faced mask self-contained breathing apparatus which provides eye protection (see NFPA for details). F1: Materials that must be preheated before ignition can occur (see NFPA for details). R0: Materials which are normally stable even under fire exposure conditions and which are not reactive with water (see NFPA for details). *OTHER TOXICITY DATA: Skin and Eye Irritation Data: eye-rbt 162 mg MOD eye-rbt 10 mg MLD eye-rbt 500 mg/24H MLD skn-rbt 810 mg/24H SEV skn-rbt 100 mg/24H MOD Review: Toxicology Review Standards and Regulations: DOT-Hazard: ORM-A; Label: None DOT-IMO: Poison B; Label: St. Andrews Cross Status: EPA Genetox Program 1988, Positive: Cell transform.-RLV F344 rat embryo EPA Genetox Program 1988, Positive: Histidine reversion-Ames test EPA Genetox Program 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis EPA Genetox Program 1988, Positive: S cerevisiae-reversion EPA Genetox Program 1988, Negative: D melanogaster Sex-linked lethal EPA TSCA Chemical Inventory, 1986 EPA TSCA 8(a) Preliminary Assessment Information, Final Rule EPA TSCA Section 8(e) Status Report 8EHQ-0680-0345 EPA TSCA Section 8(e) Status Report 8EHQ-0180-0324 EPA TSCA Test Submission (TSCATS) Data Base, June 1989 NIOSH Current Intelligence Bulletin 46, 1986 NIOSH Analytical Methods: see Methylene chloride, 1005 Meets criteria for proposed OSHA Medical Records Rule OSHA Analytical Method #ID-59 IDLH level: 5000 ppm [051,371] -OTHER DATA (Regulatory) ======================= *PROPER SHIPPING NAME (IATA): Dichloromethane *UN/ID NUMBER: UN1593 *HAZARD CLASS: 6.1 SUBSIDIARY RISK: None PACKING GROUP: III *LABELS REQUIRED: Keep away from food *PACKAGING: PASSENGER: PKG. INSTR.: 605, Y605 MAXIMUM QUANTITY: 60 L, 2 L CARGO : PKG. INSTR.: 612 MAXIMUM QUANTITY: 220 L *SPECIAL PROVISIONS: None *USES: This compound is used in rubber adhesives and other rubber solutions, in the pharmaceutical industry, as a paint and varnish remover, in solvent degreasing, in aerosol formulations, in food and drug processing, in the plastic industry, in hairsprays, insecticides and spray paints, as a cosolvent or vapor pressure depressant, as a blowing agent for flexible polyurethane foams, as a cleaning solvent for circuit boards, as a stripper solvent for photoresists, as a solvent for cellulose acetate fiber, in plastic film, in protective coatings, in chemical processing, as a carrier solvent for herbicides and insecticides, to extract heat-sensitive, naturally occurring substances such as cocoa, edible fats, spices and beer hops, for decaffeinating coffee, as a refrigerant, in oil dewaxing, as a dye and perfume intermediate, in the textile industry, as a post-harvest fumigant for strawberries, as a grain fumigant, for degreening citrus fruits, as an industrial solvent, in low temperature extraction, as a solvent for oil, fats, bitumen and esters, in coating photographic films, as a solvent for resins and rubber, as a food additive, in synthetic fibers and leather coatings, as a spotting agent and in organic synthesis. *COMMENTS: Carbon monoxide is a metabolite of this compound [058,151,173]. -HANDLING PROCEDURES =================== *ACUTE/CHRONIC HAZARDS: This compound is moderately toxic by all routes [051]. It is an irritant of the skin, eyes and respiratory tract [102,451]. It is readily absorbed through the skin [051,058,151,395]. When heated to decomposition it emits toxic fumes of chlorine, hydrogen chloride gas, carbon monoxide, carbon dioxide and phosgene [043,058,102]. *MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. *RECOMMENDED GLOVE MATERIALS: Permeation Test Results For The Neat (Undiluted) Chemical: The permeation test results for the neat (undiluted) chemical are given below. The breakthrough times of this chemical are given for each glove type tested. The table is a presentation of actual test results, not specific recommendations or suggestions. Avoid glove types which exhibit breakthrough times of less than the anticipated task time plus an adequate safety factor. If this chemical makes direct contact with your glove, or if a tear, puncture or hole develops, replace them at once. Glove Type Model Number Thickness Breakthrough Time PVA Edmont 25-545 0.33 mm 480 min Viton North F-091 0.28 mm 52 min Nitrile North LA-1426 0.36 mm 4 min *RECOMMENDED RESPIRATOR: When working with this chemical, wear a NIOSH-approved full face positive pressure supplied-air respirator or a self-contained breathing apparatus (SCBA). [651] *OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. *STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. If possible, it would be prudent to store this compound under inert atmosphere. *SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. *DISPOSAL AND WASTE TREATMENT: Not available -EMERGENCY PROCEDURES ==================== *SKIN CONTACT: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. *INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Respirator Recommendation. *EYE CONTACT: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. *INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. *SYMPTOMS: Symptoms of exposure to this compound may include headache, elevated blood concentrations of carboxyhemoglobin, nausea and irritation of the skin and eyes [058,102,295]. Central nervous system depression, pulmonary edema, hemolysis, chronic intoxication and paresthesia may also occur [295]. Other symptoms include narcosis, temporary neurobehavioural effects, increase in serum bilirubin, increased urinary formic acid concentrations and increased risk of spontaneous abortion [395]. In addition, intravascular hemolysis, unconsciousness, lack of response to painful stimuli, rapid followed by slowed respiration, erythema, blistering, toxic encephalopathy, painful joints, swelling of the extremities, mental impairment, diabetes, skin rash, aspiration pneumonia, gross hematuria, reduction of blood pH, gastrointestinal injury and narrowing of the intestinal lumen may also occur [301]. Other symptoms may include upper respiratory tract irritation, giddiness, stupor, irritability, numbness, tingling in the limbs and hallucinations [346,421]. A dry, scaly and fissured dermatitis, skin burns, coma and death may also result [346]. Other symptoms may include dizziness, sense of fullness in the head, sense of heat, dullness, lethargy and drunkenness [058,430]. In addition, mental confusion, lightheadedness, vomiting, weakness, somnolence, lassitude, anor- exia, depression, fatigue, vertigo, liver damage, nose and throat irritation, anesthetic effects, smarting and reddening of the skin, blood dyscrasias, acceleration of the pulse and congestion in the head may result [051]. Stag- gering may also occur [102]. Other symptoms of exposure to this compound may include neurasthenic disorders, digestive disturbances and acoustical and optical delusions [421]. Arrhythmias produced by catecholamines may also result [406]. Additional symptoms include edema, faintness, loss of apetite and apathy [173]. Hyporeflexia, gross hemoglobinuria, epiglottal edema, metabolic acidosis, gastrointestinal hemorrhage, ulceration of the duodeno- jejunal junction and diverticula may also occur [151]. 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